fbpx
Menu

Articles

Explore the science behind hair loss and hair growth. Our in-depth articles cover topics ranging from natural remedies to pharmaceuticals to breakthroughs in hair loss science. Want to request an article topic? Contact us.

Ingredients
Pharmaceuticals
Natural Remedies
Company Reviews
PTGES2: Can This Gene Predict Regrowth from Minoxidil?
By Sarah King, PhD
Aug 21, 2024

PTGES2: Can This Gene Predict Regrowth from Minoxidil?

The PTGES2 gene encodes the enzyme prostaglandin E synthase 2, which is crucial for converting prostaglandin H2 to prostaglandin E2 (PGE2). This enzyme plays a significant role in various physiological processes, including inflammation and hair growth. Research has indicated that an SNP in the PTGES...
PGTFR: Can This Gene Predict Regrowth From PGF2a Analogs?
By Sarah King, PhD
Aug 21, 2024

PGTFR: Can This Gene Predict Regrowth From PGF2a Analogs?

Can your genes predict the effectiveness of PGF2α analogs for hair loss? The PGFTR gene, encoding the prostaglandin F2 alpha (PGF2α) receptor, is a potential target in hair loss treatment. Prostaglandin F2α and its analogs like latanoprost have been shown to stimulate hair follicle growth, making PG...
IGF1R: Can This Gene Predict Regrowth From IGF-1?
By Ben Fletcher, PhD
Aug 20, 2024

IGF1R: Can This Gene Predict Regrowth From IGF-1?

The IGF1R gene encodes the insulin-like growth factor-1 receptor, which is integral to the IGF signaling pathway, particularly in processes like growth and development. Variations in the IGF1R gene, such as the rs2229765 polymorphism, have been linked to differences in circulating IGF-1 levels, with...
SRD5A1 & 2: Can These Genes Predict Regrowth From 5-Alpha-Reductase Inhibitors?
By Ben Fletcher, PhD
Aug 6, 2024

SRD5A1 & 2: Can These Genes Predict Regrowth From 5-Alpha-Reductase Inhibitors?

Can your genes predict the effectiveness of 5α-reductase inhibitors for hair loss? The SRD5A1 and SRD5A2 genes, encoding type I and type II 5α-reductase respectively, are central to DHT production, a key factor in the pathogenesis of androgenic alopecia. Genetic testing companies suggest certain SR5...
GPR44: Can This Gene Predict Hair Regrowth From PGD2 Inhibitors?
By Sarah King, PhD
Jul 16, 2024

GPR44: Can This Gene Predict Hair Regrowth From PGD2 Inhibitors?

Can your genes predict the effectiveness of PGD2 inhibitors for hair loss? The GPR44 gene, encoding the prostaglandin D2 receptor (DP2), is a potential target in hair loss treatment. Elevated levels of prostaglandin D2 (PGD2) have been linked to hair growth inhibition, making GPR44 a key player. How...
SULT1A1: Can This Gene Predict Hair Regrowth From Minoxidil? | The Evidence
By Sarah King, PhD
Jul 16, 2024

SULT1A1: Can This Gene Predict Hair Regrowth From Minoxidil? | The Evidence

Can your genes predict minoxidil effectiveness? The SULT1A1 gene, which encodes sulfotransferase, might hold the key, at least according to gene testing companies. SULT1a1 codes for an enzyme that activates minoxidil, a common hair loss treatment. While some studies suggest certain SULT1A1 variants ...
Microneedling the Scalp: Does it Cause Scarring?
By Sarah King, PhD
May 31, 2024

Microneedling the Scalp: Does it Cause Scarring?

Can repeated microneedling on the scalp cause scarring? There aren’t yet long-term studies answering this question. On the one hand, microneedling increases neocollagenesis (i.e., the formation of new collagen, or skin tissue). On the other hand, studies show that microneedling-induced collage...
Pyrilutamide (KX-826): A Promising Future Treatment For Hair Loss?
By Sarah King, PhD
May 9, 2024

Pyrilutamide (KX-826): A Promising Future Treatment For Hair Loss?

Pyrilutamide, also known as KX-826, is an anti-androgen topical currently being tested for the treatment of androgenic alopecia (AGA). Initial studies suggested that pyrilutamide might help reverse hair loss. However, larger-scale clinical studies have found no significant differences in hair regrow...
HMI-115: What We Know So Far
By Sarah King, PhD
May 9, 2024

HMI-115: What We Know So Far

HMI-115 lowers prolactin levels and is currently in clinical trials for the treatment of androgenic alopecia (AGA). Internal, non-peer-reviewed research suggests that HMI-115 may promote hair regrowth in monkeys. Anecdotes from its phase I trials in humans imply that HMI-115 may also regrow hair in ...
Green Tea: Is It An Effective Hair Loss Treatment?
By Sarah King, PhD
May 2, 2024

Green Tea: Is It An Effective Hair Loss Treatment?

Green tea extract contains epigallocatechin gallate (EGCG) and many other compounds that allegedly improve hair growth. On the one hand, in vitro studies suggest that EGCG might inhibit hair follicle damage. On the other hand, human studies do not yet exist showing that green tea – as a supplement o...

Stop guessing which hair loss
treatments actually work

Instead, just read our cheat sheet

You’ll get the facts on nine “natural” and “conventional” hair loss treatments: how they work, how much hair they’ll regrow, their limitations, and what their marketers don’t want you know.